The effect of pregnancy in Parkinson's disease
Identifieur interne : 004946 ( Main/Exploration ); précédent : 004945; suivant : 004947The effect of pregnancy in Parkinson's disease
Auteurs : Lisa M. Shulman [États-Unis] ; Alireza Minagar [États-Unis] ; William J. Weiner [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2000-01.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
- Adult, After effect, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Carbidopa (administration & dosage), Carbidopa (adverse effects), Case study, Disease Progression, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Combinations, Estrogen, Evolution, Female, Follow-Up Studies, Humans, Infant, Newborn, Levodopa (administration & dosage), Levodopa (adverse effects), Neurologic Examination (drug effects), Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Pregnancy, Pregnancy Complications (diagnosis), Pregnancy Complications (drug therapy), Puerperium, Quality of Life, Quality of life.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Carbidopa, Levodopa.
- chemical , adverse effects : Antiparkinson Agents, Carbidopa, Levodopa.
- diagnosis : Parkinson Disease, Pregnancy Complications.
- drug effects : Neurologic Examination.
- drug therapy : Parkinson Disease, Pregnancy Complications.
- Adult, Disease Progression, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Combinations, Female, Follow-Up Studies, Humans, Infant, Newborn, Pregnancy, Quality of Life.
Abstract
Pregnancy in patients with Parkinson's disease (PD) is a rare occurrence. Previous reports based on retrospective analysis suggest that pregnancy may have a deleterious effect on PD. We describe the effects of pregnancy on the symptomatology of a 33‐year‐old woman with PD using quantitative neurologic and quality‐of‐life scales prepartum, intrapartum, and postpartum. During her pregnancy, she was only treated with carbidopa/levodopa. The pregnancy resulted in a normal full‐term vaginal delivery of a healthy infant. Significant worsening of this patient's motor symptoms occurred during pregnancy without return to baseline at 15 months postpartum. Pregnancy may exacerbate PD and may have a long‐term negative impact on the course of the illness. This report may assist physicians in the counseling of patients with young‐onset PD who wish to consider pregnancy.
Url:
DOI: 10.1002/1531-8257(200001)15:1<132::AID-MDS1020>3.0.CO;2-C
Affiliations:
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Le document en format XML
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<term>Carbidopa (administration & dosage)</term>
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<term>Case study</term>
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<term>Pregnancy</term>
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<term>Pregnancy Complications (drug therapy)</term>
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<term>Dose-Response Relationship, Drug</term>
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<term>Femelle</term>
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<term>Parkinson maladie</term>
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<front><div type="abstract" xml:lang="en">Pregnancy in patients with Parkinson's disease (PD) is a rare occurrence. Previous reports based on retrospective analysis suggest that pregnancy may have a deleterious effect on PD. We describe the effects of pregnancy on the symptomatology of a 33‐year‐old woman with PD using quantitative neurologic and quality‐of‐life scales prepartum, intrapartum, and postpartum. During her pregnancy, she was only treated with carbidopa/levodopa. The pregnancy resulted in a normal full‐term vaginal delivery of a healthy infant. Significant worsening of this patient's motor symptoms occurred during pregnancy without return to baseline at 15 months postpartum. Pregnancy may exacerbate PD and may have a long‐term negative impact on the course of the illness. This report may assist physicians in the counseling of patients with young‐onset PD who wish to consider pregnancy.</div>
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